USP(U.S. Pharmacopela / National Formulary)
PYRIDOXINE HYDROCHLORIDE RENAUDIN;2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine;2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin;2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine;2-Picoline-4,5-dimethanol, 3-hydroxy-;3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-;3-hydroxy-2-picoline-5-dimethanol;3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine
White to off-white crystaline powder
Pyridoxine hydrochloride provides pyridoxine, which is also known as vitamin B6. Vitamin B6 is naturally found in foods such as cereals, beans, vegetables, liver, meat, and eggs. Vitamin B6 functionalizes as a coenzyme in the metabolism of protein, carbohydrate, and fat. Vitamin 6 is needed to maintain the health of nerves, skin, and red blood cells. Pyridoxine is used to prevent or treat vitamin B6 deficiency caused by inadequate dietary intake. It is also used to treat drug induced deficiency in patients taking isoniazid or oral contraceptives.
s Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis.